Oct 15, 2020

Fund for startups launches to drive innovation in healthcare

digital healthcare startup
research
Innovation
funding
Leila Hawkins
2 min
Fund for startups launches to drive innovation in healthcare
The fund will help up to four projects per year...

The Pistoia Alliance, a non-profit healthcare and life sciences members’ organisation, has launched a new fund to help healthcare and biopharma startups create new projects.

The Innovation Seed Fund aims to fund three to four new projects per year to research and develop prototypes and proof of concepts (POC), primarily focusing on ideas that help patients gain more control over their healthcare, emerging science and technology, research and development, and data standards and regulatory. 

It is hoped the fund will enable more POCs to be created, as many ideas never reach fruition due to a lack of initial funding. Additionally around 90 per cent of digital healthcare startups fail in their first five years due to lack of funding, not having a viable business model, or not having enough stakeholders. 

“The Innovation Seed Fund is to help advance ideas, develop strong business cases, and drive wider membership engagement into these projects” commented Kathy Gibson, Innovation and Investment Advisor at Pistoia Alliance. 

“In this digital age there are so many opportunities to enhance the patient experience, this fund helps to make these initiatives feasible, lowering the risk and costs for individual businesses. On average, a quarter of startups fail in the first year, the Alliance is dedicated to preventing this from happening to innovations that can empower patients and improve healthcare and biopharma for all.”

For the last four years The Pistoia Alliance has helped 20 finalists to raise more than $45 million in funding through its President's Challenge, leading to employment for over 200 people in the life sciences sector. 

“The Innovation Seed Fund enables us to help organizations bring together the skills and funding they need to start new initiatives in healthcare and biopharma R&D regardless of their size, lowering the risks for the whole industry” Dr. Steve Arlington, President of the Pistoia Alliance said. 

“This is a great opportunity for us to support companies and patient-led groups exploring new ideas and will give Pistoia Alliance members visibility of unique and interesting initiatives. By enabling more POCs to be created from early stage ideas we hope it will allow many to reach the point where they can go on to gain venture capital investment or further momentum within our community. Currently, countless great ideas never reach fruition as innovators don’t have the initial funds to develop a POC.”

Founded in 2007, The Pistoia Alliance members belong to the technology, life sciences, publishing and academic sectors. There are currently over 150 member companies collaborating on projects for the worldwide life sciences R&D community. 

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Jun 14, 2021

Long haul Covid, the brain and digital therapies

#longcovid
#digitaltherapy
#neuroplasticity
#covid19
4 min
Neuroplasticity expert Ashok Gupta tells us about the symptoms of long Covid, how it affects the brain, and digital therapies

It is estimated that around 10% of people who get Covid-19 develop long haul Covid, a debilitating condition that can last many months and cause breathlessness, exhaustion and pain. 

Research is underway to find out who is more likely to get it and how to treat it. Here neuroplasticity expert and owner of Harley Street Solutions in London Ashok Gupta tells us how the condition affects the brain. 

What is long Covid exactly? 

Long Covid is when patients who have experienced Covid-19 go on to have continuing symptoms for weeks and months afterwards. These symptoms can include breathlessness, exhaustion, brain fog, gastric issues, pain, and post-exertional malaise. It is estimated that around 10% of Covid-19 infections may result in developing long haul symptoms, and in the USA, this may be affecting over 3 million people.

How does it affect the brain?
Here at our clinic, we hypothesise that it is due to a malfunction in the unconscious brain, creating a conditioned response that keeps the body in a hyper-aroused state of defensiveness. At the core of this hypothesis is the idea that we are here because our nervous system and immune system have evolved to survive. We are survival machines!

When we encounter something such as Covid-19, the brain perceives it as life threatening, and rightly so. And in the era of the pandemic, with more stress, anxiety and social isolation, our immunity may be compromised, and therefore it may take longer for the immune system to fight off the virus and recover. 

If the brain makes the decision that this is potentially life threatening and we get to the stage where we’re overcoming the virus, a legacy is left in the brain; it keeps over-responding to anything that reminds us of the virus. Even if we’ve fought off the virus, the brain will react in a precautionary way to stimuli reminiscent of the virus. 

The brain may get stuck in that overprotective response, and keeps stimulating our nervous system and our immune system, just in case the virus may still be present.

What symptoms does this cause? 

These signals cause a cascade of symptoms including breathlessness, extreme fatigue, brain fog, loss of taste or smell, headaches, and many others. And these are caused by our own immunes system.

In the case of long-haul Covid, symptoms in the body get detected by a hypersensitive brain which thinks we’re still in danger. The brain then chronically stimulates the immune and nervous systems, and then we have a continuation of a chronic set of symptoms.

This isn’t unique to long-haul Covid. Many patients develop chronic fatigue syndrome, sometimes known as “ME”, for example, after the flu, a stomach bug, or respiratory illness. Covid-19 may be a severe trigger of a form of chronic fatigue syndrome or ME.

How does long-haul Covid affect mental health? 
Anxiety is a very common symptom in long haulers. It can be frightening to wonder about what may be happening in your body, and what the prognosis is going to be for one’s long term health. Reaching out for support for mental health is crucial for long-haulers.

How does neuroplasticity treatment work for long-haul COVID patients?
We have been working with patients for two decades with a brain retraining programme using neuroplasticity or “limbic retraining.” 

We believe that through neural rewiring, the brain can be “persuaded” that we are no longer in danger and to come back to homeostasis. But to be very clear, we are not saying it is psychological in any way, but we believe there are novel ways of accessing the unconscious brain. 

We recently worked successfully with a 56-year-old male with long-haul Covid, who prior to contracting Covid-19 in March of 2020 was running half-marathons and cycling, but afterwards he struggled to get off the sofa for months. Within 3 months he’s now back to 100% and  running half marathons again.

At our clinic, we train the patient to be able to recognise those subtle unconscious danger signals on the periphery of consciousness. This, coupled with supportive techniques and the natural hallmarks of good health such as sleep and diet help prepare the patient to respond to perceived threats that might trigger the response. 

The natural state of our brain is to default to protection. The brain prioritises survival and passing on our genes to the next generation, over any other impulse. It cares more about that than you feeling healthy and well. Protective responses are evolutionary, and are the right thing for the brain to do – it’s survival. 

What digital therapies or apps are proving effective at treating long-haul Covid? 
It seems that long haul patients are availing themselves of many online therapies and services, including meditation apps and wellness websites. We have an online neuroplasticity “brain retraining” video course called the “Gupta Program” which hosts 15 interactive videos and many audio exercises. This is proving very popular with long haul patients, and we are currently conducting a trial to test the effectiveness of this therapy. 

What is the danger of leaving long-haul Covid untreated?
The longer it goes untreated, we hypothesise that it may become more entrenched in the brain, and  become chronic in the longer term. Therefore we advise all patients to get help and advice as soon as possible.

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