Ibuprofen, aspirin and paracetamol stop Prozac working
Written By: Abbie Smith
Prozac is one of the most popularly prescribed anti-depressant treatments but new research has found that aspirin, paracetamol and ibuprofen may reduce its effect.
There have been complaints that anti-depressants, also dubbed as ‘happy pills’, do nothing to boost patients moods or lift them out of a depression.
Scientists believe they have now discovered why many people have complained that the serotonin uptake inhibitors (SSRIs) are ineffective, after a study found that their effects are reduced when they are taken alongside ibuprofen, aspirin or paracetamol.
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Non-steroidal anti-inflammatory drugs (NSAIDs) are a widely used class of pain medication.
One of the lead researchers of the project, Jennifer Warner-Schmidt, said: “It appears there's a very strong antagonistic relationship between NSAIDs and SSRIs.”
She added that this might be why the response rate in patients taking SSRIs is so low.
The researchers said the findings need to be confirmed in further studies, and it wasn’t clear if the effect of SSRIs was diminished from someone taking ibuprofen for an occasional headache, or if it was affected through the long-term use of pain medication for conditions like arthritis.
Prozac is prescribed to two million people a year in Britain, while 253 million people in the US were prescribed anti-depressants in 2010.
The National Institute of National Health also states that 16.5 per cent of adults in the US will suffer from major depression during their lifetime.
The team of researchers from the Rockefeller Univeristy in New York studied the effects of the two medications in mice.
A group of ‘depressed’ mice were given anti-depressants and half of them were also given painkillers.
The scientists tracked the changes in their behaviour and noted that Prozac and other related drugs were less effective in the mice that also had painkillers in their system.
The researchers said: “The mechanism underlying these effects is not yet clear. Nevertheless, our results may have profound implications for patients.”
A study of medical records also found that there were similar effects in people who were taking both SSRIs and NSAIDs, with SSRIs successful in 40 per cent of people who were also taking NSAIDs, as opposed to a 54 per cent success rates in people who were taking SSRIs on their own.
The researchers believe this effect could be particularly severe in the elderly, as depression often leads to Alzheimer’s.
“Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both anti-depressant and anti-inflammatory medications,” said Dr Paul Greengard.
In previous studies, results showed that anti-depressants were not much more effective than dummy pills, and only in extreme cases of depression did Prozac, Seroxat and Efexor improved mental health.
LG launches purpose-built smart TV for hospitals
LG Business Solutions USA has announced two new hospital TVs that are designed to improve patient management and engagement while adhering to critical safety standards for healthcare facilities.
One of the TVs is LG's biggest ever screen for a hospital - the 65-inch 4K Ultra HD model. It has LG’s NanoCell display technology, enabling it to display vivid pictures, and provides built-in support for hospital pillow speakers and embedded broadband LAN capability, so hospitals can deliver video on demand without requiring a separate set-top box in the patient room.
It also includes configuration software with an intuitive interface for setting up the TV to work in a hospital setting, plus a software-enabled access point feature that turns the TV into a Wi-Fi hotspot.
The second TV screen is the 15-inch Personal Healthcare Smart Touch TV with a multi-touch screen. It is designed to be installed on an adjustable arm for use in shared spaces or smaller patient rooms and will support LG's new, modular LG AM-AC21EA video camera, and HD video communication.
Both include support for video conferencing, and are UL Certified for use in healthcare facilities, a global safety standard. They also feature LG’s integrated Pro:Centric hospital management solutions, allowing hospitals and LG’s patient engagement development partners to personalise a patient's room, providing entertainment, hospital information, services, patient education, and more.
Additionally its communication platform makes it possible to conduct video calls between patients and clinicians or family.
“Our newest LG hospital TVs reflect ongoing feedback from the industry and include capabilities integrated to meet the unique needs of a critical market” said Tom Mottlau, Director of Healthcare Solutions, LG Electronics USA.
“Our healthcare patient engagement development partners requested an upgradable version of webOS for our Pro:Centric smart TV platform so they could more easily introduce new features for their hospital customers. For the latest versions of webOS, LG worked closely with our partners to make their request a reality and to deliver a hospital TV platform that can evolve over time.”