UCSF awarded grants to study Alzheimer’s disease
Two individual groups of UC San Francisco researchers have been awarded Allen Distinguished Investigator (ADI) grants of more than $1 million each, according to the school.
The grants were awarded from The Paul G. Allen Family Foundation to “understand the cellular machinery underlying the neurodegenerative effects of Alzheimer’s disease.”
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In patients with Alzheimer’s disease, dying brain cells accumulate clumps of proteins that are tough to dissolve. The mystery researchers are trying to solve is why neurons fail to dissolve these molecules.
Aimee Kao, MD, PhD, assistant professor of neurology, and her collaborators Diane L. Barber, PhD, professor and chair of the Department of Cell and Tissue Biology, Matt Jacobson, PhD, professor of pharmaceutical chemistry and Torsten Wittman, PhD, associate professor of cell and tissue biology, aim to use their three-year ADI grant of $1.3 million to test cellular pH.
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“Most people, including myself, would say…the pH changes are simply a reflection of the poor health of the neurons,” said Kao. “Our hypothesis now is that the pH changes are an earlier event in the development of disease.”
On a separate, three-year, $1.4 million ADI grant, Michael Keiser, PhD, assistant professor of pharmaceutical chemistry, Martin Kampmann, PhD, assistant professor of biochemistry and biophysics, and David Kokel, PhD, assistant professor of physiology, plan to combine three innovative techniques at the Institute for Neurodegenerative Diseases to understand how networks of genes and proteins drive Alzheimer’s disease.
Using a “systems pharmacology” approach, the group plans to analyze 500,000 drug compounds to understand how they influence networks of genes controlling disease processes in cells. They also plan to use functional genomics and a zebrafish model of Alzheimer’s disease to understand how cells handle neurodegenerative processes.
“Few researchers in the field so far have combined such broad, unbiased views of what the cell might be doing when it’s trying to deal with these neurodegenerative processes,” said Keiser.
LG launches purpose-built smart TV for hospitals
LG Business Solutions USA has announced two new hospital TVs that are designed to improve patient management and engagement while adhering to critical safety standards for healthcare facilities.
One of the TVs is LG's biggest ever screen for a hospital - the 65-inch 4K Ultra HD model. It has LG’s NanoCell display technology, enabling it to display vivid pictures, and provides built-in support for hospital pillow speakers and embedded broadband LAN capability, so hospitals can deliver video on demand without requiring a separate set-top box in the patient room.
It also includes configuration software with an intuitive interface for setting up the TV to work in a hospital setting, plus a software-enabled access point feature that turns the TV into a Wi-Fi hotspot.
The second TV screen is the 15-inch Personal Healthcare Smart Touch TV with a multi-touch screen. It is designed to be installed on an adjustable arm for use in shared spaces or smaller patient rooms and will support LG's new, modular LG AM-AC21EA video camera, and HD video communication.
Both include support for video conferencing, and are UL Certified for use in healthcare facilities, a global safety standard. They also feature LG’s integrated Pro:Centric hospital management solutions, allowing hospitals and LG’s patient engagement development partners to personalise a patient's room, providing entertainment, hospital information, services, patient education, and more.
Additionally its communication platform makes it possible to conduct video calls between patients and clinicians or family.
“Our newest LG hospital TVs reflect ongoing feedback from the industry and include capabilities integrated to meet the unique needs of a critical market” said Tom Mottlau, Director of Healthcare Solutions, LG Electronics USA.
“Our healthcare patient engagement development partners requested an upgradable version of webOS for our Pro:Centric smart TV platform so they could more easily introduce new features for their hospital customers. For the latest versions of webOS, LG worked closely with our partners to make their request a reality and to deliver a hospital TV platform that can evolve over time.”