Oct 14, 2020

AI-based BP monitor "more accurate than traditional devices"

AI
blood pressure monitor
wireless monitor
Leila Hawkins
3 min
AI-based BP monitor "more accurate than traditional devices"
Biobeat's cuffless blood pressure monitor showed more reliable results during clinical trial...

A clinical trial has found that a cuffless blood pressure monitor has a higher rate of accuracy than conventional monitoring devices used by doctors. 

Biobeat, a manufacturer of wearable healthcare tech, has created a wireless, cuffless device suitable for use outside of the doctor's office that uses a type of monitoring called PPG (photoplethysmography-based monitoring). 

When measured against a standard cuff-based monitor, the cuffless device detected changes in blood pressure more accurately over time, for patients with both normal and high blood pressure, and not only when the blood pressure was stable.

The study involved measurements from 1,057 candidates, with 491 receiving a second measurement after a short five minutes of strenuous walking. The candidates averaged 66 years of age, had an average BMI of normal to high (mildly overweight), and 9.1 per cent were previously diagnosed with hypertension.

The trial's results showed that the mean value of the differences in systolic and diastolic measurements for all subjects was less than 5.0 mmHg. In the findings published in Nature.com, researchers said the readings "indicate that Biobeat’s novel PPG-based device can accurately and reliably detect and follow changes in blood pressure over time for patients with both normal and high blood pressure, and not only when the blood pressure is stable."

Researchers also said there are known discrepancies between measurements taken at home and those taken at the doctor's practice, such as "white coat hypertension", when a person becomes anxious at having their blood pressure taken which causes an abnormally high reading. For this reason expanding the use of home blood pressure monitoring is important.

“Patients with hypertension require a holistic approach to care, necessitating frequent home-based and ambulatory blood pressure monitoring to provide consistent and accurate patient readings” said Prof. Arik Eisenkraft, Chief Medical Officer of Biobeat. 

“The findings from this study demonstrate the accuracy and reliability of Biobeat’s PPG-based device for home and ambulatory measurements. Additionally, the cuffless PPG-based monitor is a viable option for out-of-office blood pressure monitoring, even in challenging clinical settings, allowing for replacement of cumbersome cuff-based automatic blood pressure monitoring devices.”

The device has been designed so that it can be easily used on a day-to-day basis. "This study proves the efficacy of our PPG-based device, which is also simpler to place and use than traditional cuff-based devices" said Arik Ben Ishay, CEO of Biobeat. 

"As a wearable device, the design also improves patient compliance without disrupting daily routines. These findings represent an evolution within the healthcare continuum, sparking a change in the way blood pressure will be monitored in the near future, in pre-hospital and in-hospital settings, as well as long-term home care scenarios.”

Biobeat's other products include a disposable short-term chest-monitor that uses AI to monitor blood pressure, pulse, temperature and cardiac output. Aggregated patient health data is viewed by medical staff via Biobeat’s secure HIPPA and GDPR compliant cloud-based patient management platform. This uses algorithms to provide alerts on patient health status and potential deterioration. 

The company's wearable devices are already being sold in more than 20 countries, including the US, Germany, France, Belgium and Italy, where hospitals and pharma companies are using them and providing them to their patients. 

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Jun 22, 2021

Bachem turns 50 - a timeline

pharma
supplychain
peptides
medication
3 min
As Bachem turns 50, we take a look at the company's history

Bachem, a supplier to pharmaceutical and biotechnology companies worldwide, is celebrating its 50th anniversary this month. We take a look at the Swiss company's history.  

1971 - beginnings

Bachem is founded by entrepreneur Peter Grogg in Liestal, a small town near Basel in Switzerland. Grogg started the firm with just two employees, and with a focus on peptide synthesis - peptides are composed of amino acids that have a variety of functions treating health conditions such as cancer and diabetes. 

1977 - 1981 - early growth

Bachem moves its headquarters to the Swiss town of Bubendorf, with eight employees. In 1978 the company produces peptides for use in medicines for the first time. In 1981 production capacity triples and the workforce grows to 150. 

 1987 - 1996 - worldwide expansion

The company expands into the US with Bachem Bioscience, Inc. in Philadelphia. To strengthen its presence in Europe, Bachem opens sales and marketing centres in Germany in 1988. 

Further sales centres open in France in 1993. By 1995 the company employs 190 people. In 1996 it acquires the second largest manufacturer of peptides in the world and forms Bachem California with a site in Torrance. 

 1998 - 2003 - Bachem goes public

Bachem company goes public and lists shares on the Swiss Stock Exchange. Further acquisitions include Peninsula Laboratories, Inc, based in California, and  Sochinaz SA, a Swiss-based manufacturer of active pharmaceutical ingredients.  By 2001, the company has 500 employees and sales reach 141 million CHF.

In 2003 the organisation is given a new legal holding structure to support its continued growth, which remains in place to this day. 

2007 - 2013 - acquisitions

Bachem acquires a brand by Merck Biosciences for ready-to-use clinical trial materials and related services. 

In 2013, together with GlyTech, Inc. Bachem announces the development of a new amino acid that can help to treat multiple sclerosis, with a world market of more than $4 billion. 

In 2015 it acquires the American Peptide Company (APC), which becomes integrated into Bachem Americas. 

2016 - 2019 - a global leader

In 2016 the group opens a new building dedicated to R&D projects and small series production in Bubendorf. With a total of 1,022 employees, the workforce exceeds the 1,000 mark for the first time in the company’s history. Sales are over the 200 million mark for the first time at 236.5 million CHF.
Bachem expands into Asia with the establishment of a new company in Tokyo called Bachem Japan K.K. 

By 2019 Bachem has a growing oligonucleotide portfolio - these are DNA molecules used in genetic testing, research, and forensics. It is hoped this will become a significant product range in the future. 

2020 - COVID-19

Despite the COVID-19 pandemic, Bachem secures its supply of active ingredients, and even increases it in critical areas. Sales exceed the 400 million Swiss franc mark for the first time, and  272 new employees are hired.  

2021 - a milestone anniversary

Bachem celebrates its 50th anniversary and position as a global leader in the manufacture of peptides. While it  remains headquartered in Bubendorf, the company employs 1,500 people at six locations worldwide. In the next five years there are  plans to continue expanding. 

Commemorating the company's anniversary, Kuno Sommer, Chairman of the Board of Directors, said: "Bachem's exceptional success story from a small laboratory to a global market leader is closely linked to Peter Grogg's values, and has been shaped by innovation, consistent quality and cost awareness, as well as by entrepreneurial vision."

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