May 17, 2020

IMS Health buys analytics company TTC

benchmarking solutions and analytics company
2 min
IMS Health buys analytics company TTC
IMS Health said it has acquired benchmarking solutions and analytics company TTC that helps life science companies around the world plan for and negoti...

IMS Health said it has acquired benchmarking solutions and analytics company TTC that helps life science companies around the world plan for and negotiate costs of clinical trials.

The leading provider of information, services and Analytics Company will integrate its evidence-based, anonymized patient and treatment outcomes insights with TTC’s comprehensive cost drawn from companies that conduct nearly 80% of all the commercial clinical studies.

Philadelphia-based TTC offers its clients a robust set of clinical trial benchmarks, budgeting and negotiating tools to enhance the speed, efficiency and cost-effectiveness of their trial planning and management activities.

The benchmarking solutions firm maintains the world’s largest clinical grant benchmarking and negotiation database namely GrantPlan. It also serves 17 of the top 20 pharmaceutical companies and eight of the ten largest contract research companies.

Andrew Kress, Senior Vice President, Healthcare Value Solutions, IMS, said, “This acquisition marks an important step in further expanding IMS’s capabilities in the pharma R&D space.” Mr. Kress also said, “This combination of TTC’s portfolio and IMS information assets will fuel ongoing innovation, enabling clients to base vital budgeting and negotiation decision on real-world data and benchmarks.”

TTC’s benchmark data and budgeting services will be available through IMS’s clinical trial optimization unit, part of the company’s Healthcare Value Solutions business, the news reports said.

Harold Glass, PhD, TTC President said, “We’re extremely pleased to join the IMS team.” Mr. Glass also said, “Our clients are actively seeking more data and analytics to guide their decision making and drive improvements in a process that today is highly inefficient.” “This combination makes IMS a leading partner for healthcare organizations in the planning and execution of clinical trials built on an evidence-based foundation,” he added.

IMS Health is a global company providing information, services, and technology for the healthcare industry.

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Jun 15, 2021

 NHS trials test that predicts sepsis 3 days in advance 

2 min
Queen Alexandra Hospital is trialling a new sepsis test by Presymptom Health that uses machine learning to detect the onset of the disease

A new test that can predict sepsis before the patient develops symptoms is being trialled at a National Health Service (NHS) hospital in the south of England. 

Clinicians at Portsmouth’s Queen Alexandra Hospital are leading medical trials of the blood test, which they hope will help them save thousands of lives a year. 

The test is being developed by government spin-out company Presymptom Health, but the research began over 10 years ago at the Defence Science and Technology Laboratory (Dstl). This included a study of 4,385 patients and more than 70,000 samples, the largest study of its kind at the time. 

From the samples taken, a clinical biobank and database were generated and then mined using machine learning to identify biomarker signatures that could predict the onset of sepsis. The researchers found they were able to provide an early warning of sepsis up to three days ahead of illness with an accuracy of up to 90%.

Unlike most other tests, Presymptom Health identifies the patient’s response to the disease as opposed to detecting the pathogen. This is an important differentiator, as sepsis occurs as a result of the patient's immune system’s overreaction to an infection or injury, which can then cause life-threatening organ dysfunction. 

Worldwide, an estimated 49 million people a year contract sepsis, while in the UK almost two million patients admitted to hospital each year are thought to be at risk of developing the condition. If Presymptom's test is effective, it could save billions of pounds globally and improve clinical outcomes for millions of sepsis patients.

The initial trials at Queen Alexandra Hospital will last 12 months, with two other sites planned to go live this summer. Up to 600 patients admitted to hospital with respiratory tract infections will be given the option to participate in the trial. The data collected will be independently assessed and used to refine and validate the test, which could be available for broader NHS use within two years. 

If successful, this test could also identify sepsis arising from other infections before symptoms appear, which could potentially include future waves of COVID-19 and other pandemics.

Dr Roman Lukaszewski, the lead Dstl scientist behind the innovation, said: “It is incredible to see this test, which we had originally begun to develop to help service personnel survive injury and infection on the front line, is now being used for the wider UK population, including those fighting COVID-19.”

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