May 17, 2020

Johnson & Johnson looks to acquire Ci:z Holdings Co. Ltd for up to $2.05bn

Johnson & Johnson
M&A
M&A
Johnson & Johnson
Catherine Sturman
2 min
Johnson & Johnson
Johnson & Johnson has agreed to acquire Japanese company Ci:z Holdings Co., Ltd., which focuses on the marketing, development and distribution of a...

Johnson & Johnson has agreed to acquire Japanese company Ci:z Holdings Co., Ltd., which focuses on the marketing, development and distribution of a broad range of dermocosmetic, cosmetic and skincare products.

The move follows a significant trend, where pharmaceutical companies have sought to expand their presence across Asia, which is becoming a hotbed of innovation, particularly within healthcare and cosmetics.

The business has provided an all-cash offer to acquire all outstanding shares and its affiliates for approximately ¥230bn. The acquisition will include the company's range of brands comprising Dr.Ci:Labo, Labo Labo and Genomer line of skincare products.

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The acquisition will strengthen Johnson & Johnson's market presence in Japan with key customers, and more broadly bolster its offering in science-based, efficacious dermocosmetic brands.

"Health and beauty consumers are actively seeking science-based innovation to improve their skin," said Jorge Mesquita, Worldwide Chairman, Johnson & Johnson Consumer. "This transaction will maximise value creation for Johnson & Johnson's Consumer business by bringing in an agile innovation model and rapidly accelerating sales through our global commercialisation expertise."

The transaction will deliver a significant and immediate premium to the company's shareholders and enhance long-term growth and value creation of the Johnson & Johnson Consumer business. it will also be a springboard to build Johnson & Johnson Consumer's connected commerce capabilities by leveraging one of the largest customer relationship management databases for direct-to-consumer skincare and improve its retail presence through well-established distribution networks.

The tender offer is expected to close in the first quarter of 2019.

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Jun 15, 2021

 NHS trials test that predicts sepsis 3 days in advance 

sepsis
MachineLearning
clinicaltrial
blooddisorder
2 min
Queen Alexandra Hospital is trialling a new sepsis test by Presymptom Health that uses machine learning to detect the onset of the disease

A new test that can predict sepsis before the patient develops symptoms is being trialled at a National Health Service (NHS) hospital in the south of England. 

Clinicians at Portsmouth’s Queen Alexandra Hospital are leading medical trials of the blood test, which they hope will help them save thousands of lives a year. 

The test is being developed by government spin-out company Presymptom Health, but the research began over 10 years ago at the Defence Science and Technology Laboratory (Dstl). This included a study of 4,385 patients and more than 70,000 samples, the largest study of its kind at the time. 

From the samples taken, a clinical biobank and database were generated and then mined using machine learning to identify biomarker signatures that could predict the onset of sepsis. The researchers found they were able to provide an early warning of sepsis up to three days ahead of illness with an accuracy of up to 90%.

Unlike most other tests, Presymptom Health identifies the patient’s response to the disease as opposed to detecting the pathogen. This is an important differentiator, as sepsis occurs as a result of the patient's immune system’s overreaction to an infection or injury, which can then cause life-threatening organ dysfunction. 

Worldwide, an estimated 49 million people a year contract sepsis, while in the UK almost two million patients admitted to hospital each year are thought to be at risk of developing the condition. If Presymptom's test is effective, it could save billions of pounds globally and improve clinical outcomes for millions of sepsis patients.

The initial trials at Queen Alexandra Hospital will last 12 months, with two other sites planned to go live this summer. Up to 600 patients admitted to hospital with respiratory tract infections will be given the option to participate in the trial. The data collected will be independently assessed and used to refine and validate the test, which could be available for broader NHS use within two years. 

If successful, this test could also identify sepsis arising from other infections before symptoms appear, which could potentially include future waves of COVID-19 and other pandemics.

Dr Roman Lukaszewski, the lead Dstl scientist behind the innovation, said: “It is incredible to see this test, which we had originally begun to develop to help service personnel survive injury and infection on the front line, is now being used for the wider UK population, including those fighting COVID-19.”

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