Merck announces FDA approval for two new drugs
The meds, Delstrigo and Pife...
The US-based pharmaceutical company, Merck, has announced Food and Drug Administration (FDA) approvals for two new drugs.
The meds, Delstrigo and Pifeltro, have been granted approval to treat patients with HIV-1 who haven’t had prior antiretroviral treatments, however, do not cure the HIV infection or AIDS.
According to the press release, “Delstrigo is to be taken once a day in a fixed-dose combination tablet of doravirine, lamivudine and tenofovir disoproxil fumarate while Pifeltro is a new non-nucleoside reverse transcriptase inhibitor to be administered in combination with other antiretroviral medicines.”
- Almost 90% of American have used digital health tools, claims Rock Health
- Harris Healthcare confirms purchase of Iatric Systems
- Roland Diggelmann resigns as CEO of Roche Diagnostics after 10 years
- Read the latest issue of Healthcare Global!
It has been revealed that the meds are to be contraindicated when co-administered with drugs that are strong cytochrome P450 3A enzyme inducers as substantial reductions in doravirine plasma concentrations are thought to occur, which is feared to reduce the impact of Delstrigo and Pifeltro.
Dr. George Hanna, vice president and therapeutic area head of infectious diseases, stated: “As part of Merck’s 30-year commitment to the care of people with HIV, we are pleased to now bring forward these two new antiretroviral treatment options, Delstrigo and Pifeltro, which we believe offer a compelling clinical profile for clinicians and people living with HIV.”
“We are thankful to the researchers as well as those living with HIV and their communities for the collaboration that made today’s approval possible.”
Dexcom: changing the lives of people with type 1 diabetes
It is estimated that 9.3% of adults around the world are living with type 1 diabetes, which amounts to a total of 463 million people. A further 1.1 million children and adolescents under the age of 20 are living with the condition.
Unlike the more prevalent type 2 diabetes, where the body still produces insulin and symptoms develop slowly, people with type 1 diabetes need regular insulin injections or pumps, and must monitor their sugar levels frequently.
In recent years a number of remote glucose monitoring systems have become available that patients can use at home. These work with a sensor, usually placed under the skin, that measures glucose levels every few minutes. This information is then transmitted wirelessly to a device like a smartphone or tablet, which can then be shared with their clinician.
British actress Nina Wadia's son Aidan, 14, has type 1 diabetes, and has been managing his condition using Dexcom, a glucose monitoring system used by patients all over the world. Here Wadia explains how Dexcom has improved their lives.
As a parent of someone with type 1 diabetes, what is your day-to-day life like?
Being able to take a breath, think and pivot constantly without getting frustrated becomes an essential mindset because sometimes it feels like each day is determined to be different from the day before. Whatever worked yesterday is going to misfire today.
Which areas of yours and Aidan’s life are most impacted by diabetes?
The one thing that you have to fight hard to reclaim is spontaneity, especially when it comes to food and exercise. It’s only when this is taken do you realise how essential each one is. You can be flexible and there are no real limits, but only in the sense that a great athlete can be flexible without limits because they’ve trained super hard to be that way. So we’ve all had to become athletes when it comes to being spontaneous.
How has Dexcom helped you and Aidan?
Dexcom has brought future science fiction to real life today. The continuous glucose monitoring system is tiny, sits discreetly on his body and gives him a ten-day breather between sensor changes, so it's goodbye finger-pricking seven times daily.
Dexcom is totally active at a grass roots level and for Diabetes Awareness has pledged to donate £2,000 if #DexcomDiabetesStories and/or #DexcomWarriorStories is shared 200 times! I’ll be sharing more on social media and would love to hear how other families are winning their fights.
Maybe most importantly Dexcom is trying to introduce a reimbursement programme for type 1 diabetes patients which will give greater access to modern, life changing hi-tech. I want to spread the word on the importance of accessing it through this campaign.
If you compared your life today with how it was before Aidan was using Dexcom, what has changed?
It's always working, which lets him take his mind off diabetes for longer stretches. It also lets me get off his back. We both receive alerts so I no longer have to pester him by asking him what his number is, and especially importantly, I don’t have to wake him at night to prick his finger if I’m worried. Dexcom gave us back our sleep!