May 17, 2020

Seattle Genetics buys out Cascadian Therapeutics for $614 million

pharmaceutical
Cancer
pharmaceutical
Cancer
Catherine Sturman
2 min
research (Getty Images)
Gaining a total revenue of up to $483 million at the end of 2017, Seattle Genetics has signed a merger agreement to acquire Cascadian Therapeutics. The...

Gaining a total revenue of up to $483 million at the end of 2017, Seattle Genetics has signed a merger agreement to acquire Cascadian Therapeutics. The company will pay $10.00 per share, which equates to approximately $614 million.

The biotech company is working to strengthen its diverse portfolio and improve the lives of people with cancer by investing in antibody-based therapies, such as ADCETRIS. Similarly to Sanofi, the company is also investing in the development of novel therapies for solid tumours and blood-related cancers, in order to provide high quality treatment and positive outcomes for patients.  

Cascadian Therapeutics will therefore compliment Seattle Genetic’s strategic goals. A clinical-stage biopharmaceutical company dedicated to developing innovative product candidates for the treatment of cancer, the company houses a significantly advanced program in the treatment of multiple cancers.

Its tucatinib program, an an investigational oral, small molecule tyrosine kinase inhibitor (TKI) which is highly selective for HER2, a growth factor receptor that is overexpressed in multiple cancers, is currently being evaluated in a randomised global pivotal trial called HER2CLIMB for patients with HER2-positive (HER2+) metastatic breast cancer, including patients with or without brain metastases.

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When combined with chemotherapy and other HER2-directed agents including Herceptin and Kadcyla, the results have been well received by patients with and without brain metastases.

 “This acquisition would enhance our late-stage clinical pipeline with a potentially best-in-class, orally available and highly selective TKI for patients with HER2-positive metastatic breast cancer,” commented Clay Siegall, PhD, President and Chief Executive Officer of Seattle Genetics.

“Tucatinib would complement our existing pipeline of targeted cancer therapies, provide a third late-stage opportunity for a commercial product in solid tumours and expand our global efforts in breast cancer. It also leverages our broad expertise and resources to advance and expand the tucatinib program for patients.

“Beyond breast cancer, we believe there may be opportunities for tucatinib in other tumor types, such as HER2-positive metastatic colorectal cancer. Cascadian’s pipeline also includes a preclinical immuno-oncology agent.”

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Jun 17, 2021

Dexcom: changing the lives of people with type 1 diabetes

diabetes
glucosemonitoring
type1diabetes
insulin
3 min
British actress Nina Wadia OBE tells us how her son's life has changed since using glucose monitoring system Dexcom

It is estimated that 9.3% of adults around the world are living with type 1 diabetes, which amounts to a total of 463 million people. A further 1.1 million children and adolescents under the age of 20 are living with the condition. 

Unlike the more prevalent type 2 diabetes, where the body still produces insulin and symptoms develop slowly, people with type 1 diabetes need regular insulin injections or pumps, and must monitor their sugar levels frequently. 

In recent years a number of remote glucose monitoring systems have become available that patients can use at home. These work with a sensor, usually placed under the skin, that measures glucose levels every few minutes. This information is then transmitted wirelessly to a device like a smartphone or tablet, which can then be shared with their clinician. 

British actress Nina Wadia's son Aidan, 14, has type 1 diabetes, and has been managing his condition using Dexcom, a glucose monitoring system used by patients all over the world. Here Wadia explains how Dexcom has improved their lives. 

As a parent of someone with type 1 diabetes, what is your day-to-day life like?
Being able to take a breath, think and pivot constantly without getting frustrated becomes an essential mindset because sometimes it feels like each day is determined to be different from the day before. Whatever worked yesterday is going to misfire today. 

Which areas of yours and Aidan’s life are most impacted by diabetes? 
The one thing that you have to fight hard to reclaim is spontaneity, especially when it comes to food and exercise. It’s only when this is taken do you realise how essential each one is. You can be flexible and there are no real limits, but only in the sense that a great athlete can be flexible without limits because they’ve trained super hard to be that way. So we’ve all had to become athletes when it comes to being spontaneous.

How has Dexcom helped you and Aidan? 
Dexcom has brought future science fiction to real life today. The continuous glucose monitoring system is tiny, sits discreetly on his body and gives him a ten-day breather between sensor changes, so it's goodbye finger-pricking seven times daily. 

Dexcom is totally active at a grass roots level and for Diabetes Awareness has pledged to donate £2,000 if #DexcomDiabetesStories and/or #DexcomWarriorStories is shared 200 times! I’ll be sharing more on social media and would love to hear how other families are winning their fights.

Maybe most importantly Dexcom is trying to introduce a reimbursement programme for type 1 diabetes  patients which will give greater access to modern, life changing hi-tech. I want to spread the word on the importance of accessing it through this campaign. 

If you compared your life today with how it was before Aidan was using Dexcom, what has changed? 
It's always working, which lets him take his mind off diabetes for longer stretches. It also lets me get off his back. We both receive alerts so I no longer have to pester him by asking him what his number is, and especially importantly, I don’t have to wake him at night to prick his finger if I’m worried. Dexcom gave us back our sleep!

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