Jun 1, 2020

Now is the time for life-changing innovation 

Tom Verner, Group Managing Dir...
5 min
Many of our 'modern' inventions and, thus, way of life, have their origins in times of great hardship from wars to pandemics
In the UK, we’ve always been a nation with real pioneering spirit. This spirit and culture of innovation has never been more evident than it is curren...

In the UK, we’ve always been a nation with real pioneering spirit.  This spirit and culture of innovation has never been more evident than it is currently. 

In looking at the history of innovation, one of the most extraordinary findings is that so many of our 'modern' inventions and, thus, way of life, have their origins in times of great hardship from wars to pandemics.   

While the inventions and scientific improvements can never be justified against the devastating loss of life, they are undoubtedly something to be positive about right now – particularly as so many have ushered in great medical and societal break-throughs. 

As a company that works with innovators across the UK, we have witnessed first-hand the research and development that is currently spurring what could become world-changing inventions.

Much of what we take for granted today was developed during these very difficult times and helped shape the world:

Penicillin - the discovery of penicillin is estimated to have saved over 200 million lives. Discovered by Scottish biologist, physician, microbiologist, and pharmacologist Alexander Fleming in 1928, Howard Florey and a team of researchers later showed the potential of penicillin in a clinical setting; and it was during World War Two that the antibiotic gained most traction. 

Disease prevention - during the early twentieth century, medical knowledge of disease transmission improved as the Spanish flu pandemic accelerated public understanding of the importance of cleanliness in disease prevention. A newly developed vaccine for typhoid had stopped what was a primary cause of death among servicemen in past conflicts, and World War I inspired similar advances in influenza or flu deterrence.

The Thomas Splint - introduced by Hugh Owen Thomas, a Welsh surgeon, considered by many to be the father of modern orthopaedic surgery. His nephew, Sir Robert Jones, applied his splint during the First World War.  Before the Thomas splint was invented, 80 percent of all soldiers died from a broken femur, but by the time of a battle in 1917, over 80 percent survived, reportedly.

Sun or UV Lamps - invented by German doctor Kurt Huldschinsky, who observed undernourishment in children during World War I led to an increase of rickets, a disorder caused by a lack of Vitamin D, calcium, or phosphate that causes the weakening of bones.  In an experiment, he put four children under mercury-quartz lamps that emitted ultraviolet light and the treatment worked causing the children’s bones to become stronger. UV lamps are used around the world to treat patients who suffer from vitamin D deficiency.

The first computer - the first programmable digital computer was pioneered by the codebreakers of Britain's Bletchley Park, the centre of code-breaking during the Second World War. Colossus was a set of computers developed using thermionic valves (vacuum tubes) to perform Boolean and counting operations and is therefore regarded as the world's first programmable, electronic, digital computer.

Portable Defibrillator – often referred to as the ‘Father of Emergency Medicine’, Frank Pantridge was a Japanese POW and after the war became a cardiac consultant and invented the portable defibrillator after seeing the need to be able to urgently treat heart patients. 

Paper hankies – R&D scientists at Kimberly-Clark developed a flattened form of cellucotton while trying to develop filters for gas masks in 1914 during World War I, leading to the idea of ironing cellulose material to produce a soft tissue.  In 1924 Kleenex became the first ever paper handkerchief, especially good at stopping colds from spreading germs. 

The Ejector Seat - James Martin was a UK aircraft manufacturer who turned to flight safety after his business partner was killed in a test flight in 1942. During World War II, Martin researched escape mechanisms for the Spitfire and created an explosive charge to forcibly eject the seated pilot. To date, thousands of pilots around the world have had their lives saved by the ejector seat.

The wind-Up radio – was invented in 1991 by British inventor Trevor Baylis, after he watched a TV programme about the challenges of getting information on Aids to people living in rural Africa. Baylis set about designing one that needed no batteries and that would run off an internal generator powered by a mainspring wound by a hand crank. He was able to demonstrate it to Nelson Mandela and since then it’s been distributed all over Africa.

The humble ‘zip’ - the “hookless fastener” was perfected by Gideon Sundback during World War I. The first major order of zippers came for money belts worn by soldiers who lacked uniform pockets. While buttons remained the convention on military uniforms during the war, zippers began to be sewn into the flying suits of aviators and took off in popularity in the 1920s.

From truly life-saving inventions to essential features of our daily lives, generation upon generation of the world have been at their very best developing solutions during times of great hardship.

The Government, through UK Research and Innovation, is supporting this drive by inviting and funding projects addressing and mitigating the health, social, economic, cultural and environmental impacts of the Covid-19 outbreak.

To help play our part, The Momentum Group, is providing free R&D Tax Credit advice ensuring UK companies achieve the optimum financial benefit from HMRC. This FREE offer is available to any company that has adapted new processes or products to aid the NHS. Even if you’re not in this sector, we are urging all to seek a second opinion as your business could really benefit at this challenging time.   We have also called on the government to ensure R&D tax claims are paid within 28 days to enable our most innovative companies to maintain a healthy cash flow during this unprecedented global crisis.

Innovation is at the heart of the UK and I have great confidence that we will not only beat Covid-19 but come out stronger.  We can achieve this by working together, helping each other and delivering solutions that will prove vital in tackling pandemics now and for future generations.

By Tom Verner, Group Managing Director, Momentum R&D

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Jun 23, 2021

Introducing Dosis - the AI powered dosing platform

3 min
Dosis is an AI-powered personalised medication dosing platform that's on a mission to transform chronic disease management

Cloud-based platform Dosis uses AI to help patients and clinicians tailor their medication plans. Shivrat Chhabra, CEO and co-founder, tells us how it works. 

When and why was Dosis founded?
Divya, my co-founder and I founded Dosis in 2017 with the purpose of creating a personalised dosing platform. We see personalisation in so many aspects of our lives, but not in the amount of medication we receive. We came across some research at the University of Louisville that personalised the dosing of a class of drugs called ESAs that are used to treat chronic anaemia. We thought, if commercialised, this could greatly benefit the healthcare industry by introducing precision medicine to drug dosing. 

The research also showed that by taking this personalised approach, less drugs were needed to achieve the same or better outcomes. That meant that patients were exposed to less medication, so there was a lower likelihood of side effects. It also meant that the cost of care was reduced. 

What is the Strategic Anemia Advisor? 
Dosis’s flagship product, Strategic Anemia Advisor (SAA), personalises the dosing of Erythropoiesis Stimulating Agents (ESAs). ESAs are a class of drugs used to treat chronic anaemia, a common complication of chronic kidney disease. 

SAA takes into account a patient’s previous ESA doses and lab levels, determines the patient’s unique response to the drug and outputs an ESA dose recommendation to keep the patient within a specified therapeutic target range. Healthcare providers use SAA as a clinical decision support tool. 

What else is Dosis working on? 
In the near term, we are working on releasing a personalised dosing module for IV iron, another drug that’s used in tandem with ESAs to treat chronic anaemia. We’re also working on personalising the dosing for the three drugs used to treat Mineral Bone Disorder. We’re very excited to expand our platform to these new drugs. 

What are Dosis' strategic goals for the next 2-3 years? 
We strongly believe that personalised dosing will be the standard of care within the next decade, and we’re honored to be a part of making that future a reality. In the next few years, we see Dosis entering partnerships with other companies that operate within value-based care environments, where tools like ours that help reduce cost while maintaining or improving outcomes are extremely useful.

What do you think AI's greatest benefits to healthcare are?
If designed well, AI in healthcare allows for a practical and usable way to deploy solutions that would not be feasible otherwise. For example, it’s possible for someone to manually solve the mathematical equations necessary to personalise drug dosing, but it is just not practical. AI in healthcare offers an exciting path forward for implementing solutions that for so long have appeared impractical or impossible.

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