Startup Uses Microinjections In Retinal Drug Delivery
The company is hoping to stave off retinal blindness in some patients by using a microneedle to administer drugs to the back of the eye between the choroid and sclera. The company says this is where many sight-threatening diseases manifest themselves including wet and dry forms of age-related macular degeneration, uveitis and retinal and choroidal inflammation.
According to a statement from the company, the funding came from Santen Inc., the California-based subsidiary of Santen Pharmaceuticals Co., Ltd in Japan, and other investors including Mountain Group Capital, Hatteras Venture Partners, Georgia Research Alliance Venture Fund and Kenan Flagler Business School Private Equity Fund. Clearside also established a research collaboration agreement with Santen focused on posterior ocular diseases.
Microneedles may offer a less-invasive, more targeted and more accessible method of drug delivery, as opposed to eye drops, hypodermic needles or surgery, and may keep drugs away from other parts of the eye, where side effects may occur, the company says.
It plans to initiate clinical testing of its first candidate, CLS1001, in the first quarter of this year.
Clearside was established in January 2012 with a $4 million investment and technology licensed from the Georgia Institute of Technology and Emory University School of Medicine. It’s based in Alpharetta, Georgia, with another office in Raleigh, North Carolina.