May 17, 2020

XtalPi closes $15mn Series B funding round, attracting tech giant Google

Catherine Sturman
2 min
Attracting investors (Getty Images)
XtalPi Inc., a computation-driven pharmaceutical technology company, has announced the closure of its $15 million Series B funding round. Led by Sequoia...

XtalPi Inc., a computation-driven pharmaceutical technology company, has announced the closure of its $15 million Series B funding round. Led by Sequoia China, participation from Google and existing investor Tencent has seen the company raise over $20 million, making it one of the top-funded AI-powered biotech companies.

Founded in 2014 by a group of quantum physicists at MIT, XtalPi encompasses an elite team of researchers with multi-disciplinary expertise in physics, chemistry, pharmaceutical R&D, and algorithm design. It now houses offices in Cambridge (UK), Beijing and Shenzhen.

XtalPi offers Intelligent Digital Drug Discovery and Development (ID4) that improves the efficiency, accuracy, and success rate of drug design, solid-form drug selection, and other critical aspects of preclinical drug development.

Although Google’s search engine remains inaccessible within the Chinese market, it is ahead of the curve in investing in companies, particularly within healthcare, where it sees vast potential. The company has recently invested in a new AI facility in the country, where it has also recently signed a patent with Chinese giant Tencent.  

By combining artificial intelligence, quantum physics, and high-performance cloud computing, XtalPi can quickly and accurately predict important characteristics of small-molecule drugs and solid forms, providing time-saving insights into the safety, stability, and efficacy of drug candidates. XtalPi currently looks to partner with top global pharmaceutical companies and research organisations to further its development.

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"We believe that algorithmic power is the key to finding smarter, more effective routes for drug research and development, and we are focused on building a computational engine that empowers and expedites pharmaceutical innovation for companies worldwide," explained XtalPi Co-founder and Chairman of the Board Dr. Shuhao Frank Wen.

"The financing from Sequoia China, Google, and Tencent, who are among the top investors and innovators in AI and computer science, represents a strong endorsement of our vision and technology."

Funding will be used to further develop new computational models built on big data generated from XtalPi's high-precision computing platform, which will see the company expand its business into adjacent areas along the pharmaceutical value chain.

It will also support the construction of a prediction-driven research lab that integrates XtalPi's R&D platform with state-of-the-art wet-bench laboratory technologies. This hybrid computational-experimental facility will provide enhanced capabilities for the rational design of solid forms of drugs.

Neil Shen, Founding and Managing Partner of Sequoia China said: "XtalPi offers a unique solution to the highly empirical and challenging nature of the drug discovery and development process. Sequoia China's investment in XtalPi reflects our view that AI will transform the future of the pharmaceutical industry."

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Jun 16, 2021

NHS opens 8 clinical trial sites to assess cancer treatment

2 min
NHS and OncoHost to launch clinical trials analysing cancer patients response to immunotherapy

The UK's National Health Service (NHS) is opening eight clinical trial sites to assess patients' responses to personalised cancer therapy. 

The trials will analyse how patients diagnosed with advanced melanoma or non-small cell lung cancer respond to immunotherapy, to help predict their response to treatment.  They will be hosted at Gloucestershire Hospitals NHS Foundation Trust facilities. 

Immunotherapy helps the body's own immune system fight cancer, but while it has achieved good results for some cancer patients, it is not successful for everyone. Finding ways to predict which people will respond to the treatment is a major area of research.

OncoHost, an oncology startup,  will provide advanced machine learning technology to develop personalised strategies aiming to improve the success rate of the cancer therapy. The trials will contribute to OncoHost’s ongoing PROPHETIC study, which uses the company’s host response profiling platform, PROphet®

“Immunotherapy has achieved excellent results in certain situations for several cancers, allowing patients to achieve longer control of their cancer with maintained quality of life and longer survival,” said Dr David Farrugia, Consultant Medical Oncologist at NHS, and chief investigator of all eight NHS clinical trial sites.

“However, success with immunotherapy is not guaranteed in every patient, so this PROPHETIC study is seeking to identify changes in proteins circulating in the blood which may help doctors to choose the best treatment for each patient." 

"I am excited that Gloucestershire Oncology Centre and its research department have this opportunity to contribute to this growing field of research and I am determined that our centre will make a leading national contribution in patient recruitment.”

Previous studies in the US and Israel have shown that PROphet® has high accuracy in predicting how patients with cancer will respond to various therapies.

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